LIVING TOGETHER AS NEIGHBOURS: RETHINKING THE REASONABLENESS STANDARD IN NUISANCE LAW UNDER THE CONSTITUTION



Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis

Abstract Objectives Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses anticancer and antiangiogenic effects in some malignant t

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A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Abstract Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops).Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.Using unbiased interactomics, biochemical screening, molecular biology, and super-resolution imaging, we

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